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In particular, you need to check that NAC doesnt interact with any medicines if you happen to be taking any

Diabetes Obes Metab (2016) 18(3):25865

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Surrogate variables to correct for batch effects To account for potential batch effects , we performed surrogate variable analysis (SVA) based on the DNA methylation levels at all CpG sites located on chromosome 10 using the R/Bioconductor package sva [31]