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Glucagon-like peptide-1 receptor (GLP-1R) is highly expressed on insulinomas 8,10

While the ligand-binding function remains unclear, sequestering molecules may serve a regulatory role, preventing cytotoxic ligands from interacting with their targets

This aspect of its mechanism may influence its overall physiological effects and side-effect profile [10]

Bluish or Purplish Tongue Possible Causes: Cyanosis (poor oxygenation) Heart or lung disease Peripheral vascular issues Clinical Insight: Suggests hypoxia check O saturation, cardiac and respiratory status

12 Clinically, the presence or absence of psammoma bodies does not seem to affect the gene expression, behavior, or prognosis of these tumors

The GLP-1 receptor exists in the brain, the gut, the pancreas, the heart, and even muscle tissue