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Additionally, it downregulated the expression of ionized calcium-binding adapter molecule 1 (Iba-1), inhibited spinal cord ferroptosis and inflammatory responses, and improved gait abnormalities and limb weakness in EAE mice

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Among the explanations for joint inflammation observed during OA is the hypothesis that the low-grade systemic inflammation observed during metabolic diseases could be one of the factors initiating and aggravating the OA process 13

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