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This finding could be explained by a competition among selenoproteins for available selenium in the form of selenocysteine required for biosynthesis of the selenoproteins and for the selenium-incorporation machinery

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For example, the percentage of cells in G2/M phase increased from 5% for the control to 43% for THJ-16t upon incubation with AP probe-net (20 M)

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Prx6 operates through its function as a selenium acceptor protein, channeling reactive selenium species toward the biosynthesis of selenoproteins, especially GPX4

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