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These begin with alterations in SCFA signaling and subsequently diverge into bile acid-mediated pathways that modulate farnesoid X receptor (FXR) and Takeda G-protein-coupled receptor 5 (TGR5) activity [19 136]

The pathomechanisms of obesity-associated MASLD include lipotoxicity, inflammation, fibrogenesis, and carcinogenic risk [39], suggesting that combating obesity is a major objective in treating MASLD

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Talk to your healthcare team or gastroenterologist if you notice differences from your normal stool, such as changes in consistency, color, frequency, or smell

If a patient has not achieved at least 5% weight loss by this point, the benefit-risk profile should be reevaluated

Eva (00:28:54): Plastic, plastic surgery and weight loss