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doi: 10.1080/028418698430566
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Thank you to our sponsors AG1 (Athletic Greens): InsideTracker: Thesis: Supplements from Momentous For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Introduction & Tool 1 to Induce Lasting Dopamine (00:04:48) Sponsors (00:09:10) Upcoming (Zero-Cost) Neuroplasticity Seminar for Educators (00:09:58) What Dopamine (Really) Does (00:15:30) Two Main Neural Circuits for Dopamine (00:18:14) How Dopamine Is Released: Locally and Broadly (00:22:03) Fast and Slow Effects of Dopamine (00:25:03) Dopamine Neurons Co-Release Glutamate (00:28:00) Your Dopamine History Really Matters (00:30:30) Parkinsons & Drugs That Kill Dopamine Neurons
The silky texture delivers long-lasting hydration without heaviness or greasiness, making it ideal for both day and night routines
Why mitochondria matter As you might recall from your high school biology textbook, mitochondria are considered the powerhouses of the cell because of their role as energy suppliers, intercellular signalers, and metabolic coordinators.3 As such, theyre central to a biological process called apoptosis (cell death), which involves the disposal of damaged or abnormal cells.4 Also, apart from the nucleus, mitochondria are the only other parts of a human cell that carry DNA.5 Therefore, mitochondrial dysfunction is inextricably linked to health conditions stemming from cellular breakdown and chromosomal changes, both of which correlate with aging.6 7 Apart from primary mitochondrial diseases such as Leigh syndrome and MELAS syndrome, these health conditions include but arent limited to:8 9 10 Cancer Diabetes Heart disease Kidney diseases Neurodegenerative disorders (e.g., Alzheimers and Parkinsons) Hearing loss Eyesight abnormalities Oxidative stress Metabolic imbalance Inflammation Myalgic encephalomyelitis, or ME/CFS (potentially
Therefore, the cardio-protective effect of AMPK-mediated pathways cannot be differentiated from FAO promotion
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