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Fifteen micrograms of immobilized GST-fused ARL8B Q75L and ARL8B T34N were complexed with 0.2 mM GTPS or GDP in 500 l binding buffer (50 mM Tris pH 7.5, 150 mM NaCl, 5 mM DTT, 5 mM MgCl 2 , 0.02% Triton X100) overnight at 4 C

Novo Nordisk submitted a New Drug Application to the FDA on December 18, 2025, with FDA review expected during 2026

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