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Furthermore, it is possible that somatostatin directly inhibits glucagon secretion by binding to its receptor in the alpha cell, since GLP- 1 stimulates islet somatostatin secretion directly through the canonical GLP- 1 receptor, expressed on delta cells [71]

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This smaller size allows orforglipron to survive digestion and be absorbed as a pill, whereas the larger peptide medications would be broken down by stomach acid if taken orally

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