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As a result, Nrf2 escapes degradation and translocate to the nucleus, where it binds to Antioxidant Response Elements (AREs) within the promoter regions of target genes

Glutathione is considered to be the most important assistant of detoxification processes in the liver

The relatively short duration of the microgravity simulation in our study also limits our understanding of the long-term effects and sustained efficacy of ZNT, which needs to be addressed in future time-dependent studies

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Therefore, it might explain why post-TACE pain was not associated with an extended hospital stay in our study