Semaglutide works by mimicking a hormone called glucagon-like peptide-1 (GLP-1), which regulates appetite and food intake
Rat studies use 10 mcg/kg daily, which scales to approximately 1.6 mcg/kg in humans using allometric conversionroughly 100150 mcg daily for a 70 kg person
It costs over $300 for a 60-day supply
For others, genetic data confirms that microdosing or standard semaglutide will deliver optimal results
The insulin resistance in PCOS might also occur independently of body weight, due to inherited post-receptor defects in insulin signalling that affects metabolism and mitotic pathways, not only in classic insulin target tissues, such as skeletal muscle, liver, and adipose tissue, but also in the non-classical target tissues, such as pituitary and ovary [12, 16]
Capehorn, A.M