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Possible effects can include mild nausea, stomach upset, headache, dizziness, or a temporary change in energy or sleep

490,491 (2) Pharmacological Intervention, such as BFKB8488A, the anti-fgfr1/KLB agonist antibody mimics the effect of FGF21, and causes short-term weight loss and increases insulin sensitivity

Injections may be given weekly or biweekly for a short period when levels are low or symptoms are present

Pregnant women need physician approval and specialized formulations

The same FDA document mandates post-marketing trials to demonstrate that the novel agent does not increase cardiovascular risk by more than 30% compared to placebo (henceforth these trials were named cardiovascular outcome trial), if premarketing studies did not already demonstrate this

Rowe 2004