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The acute effects of ethanol and acetaldehyde on physiological responses after ethanol ingestion in young healthy men with different ALDH2 genotypes

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Andreassen and colleagues (J Med Chem, 2021) reported a design campaign that combined sequence substitutions to suppress fibrillation with a fatty-acid acylation that promotes albumin binding, yielding a molecule with a much longer reported plasma half-life in their preclinical models

Mena, S., Ortega, A