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However, an uncontrolled increase in their concentrations leads to a chain of unwanted radical reactions that target the main biomolecules (DNA, RNA, lipids, and proteins) and alters key processes such as nucleic acid oxidation, lipid peroxidation, thereby contributing to the loss of cellular architecture, to impaired cell signalling and, ultimately, to cell death [25, 46]

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Tilt the vial slightly so the water runs down the glass and contacts the powder gently

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The system included an inlet and an outlet system that allowed cells to seed and be perfused with culture medium or whole blood