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Recent advances in parasite biology suggest a compartmentalization of redox metabolism [5] as well as of cellular processes that are sites of drug action [6]

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Among these, an imbalance of IL-2 and IL-4 cytokines promotes the progression of hypersensitivity (Popov et al., 2011)

In addition to a reduction of GPx3 levels, we also observed in our sibling cohort a large deficiency in cystine, the limiting factor to produce glutathione, which is required as a reducing agent for GPx3 and the entire glutathione peroxidase family 30,51

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