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Histological analyses Following dissection, epididymal white adipose tissue (eWAT), inguinal white adipose tissue (iWAT) and liver were promptly fixed in a 10% formalin-buffered solution (Sigma-Aldrich)

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W., James, L., Hahn, P

Because there were potential reproductive abnormalities observed in preclinical toxicity studies in Sprague Dawley rats and cynomolgus monkeys (see Supplementary Results for complete details of these preclinical studies), out of an abundance of caution, we restricted female subjects to postmenopausal women of nonchildbearing potential