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The Bottom Line GHK-Cu is a naturally occurring copper tripeptide that stimulates collagen synthesis at picomolar concentrations, modulates over 4,000 genes, and has shown measurable wrinkle reduction and collagen improvement in clinical studies

10.3389/fimmu.2021.720363 Front Immunol

Whether GHK-Cu produces lasting skin changes, whether tolerance develops, and whether long-term copper exposure in skin has adverse effects are unanswered questions

Human microsomal prostaglandin E synthase 1: a member of the MAPEG protein superfamily

GHK-Cu may prevent oxidative stress in skin by regulating copper and modifying expression of numerous antioxidant genes

In two studies, GHK-Cu peptide effectively reduces wrinkles and sagging along the jawline and improves skin firmness and elasticity with consistent use [2]