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Circulating LH stimulates the Leydig cells of the testes to increase the synthesis and release of testosterone, while FSH stimulates testicular Sertoli cells to enhance sperm production and the release of androgen binding protein (Androgen BP)

However, more human studies are required for confirmation

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Animal data from rodent models show that pharmacological GHSR-1a stimulation during peripubertal windows alters adult hypothalamic gene expression, though whether this finding translates to humans remains untested [6]