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FOXO4-DRI eliminated fibroblasts in G0/G1 phase cell cycle arrest and selectively induced senescent keloid cells apoptosis in an in vitro model of fibroblasts and organ culture In the serum limitation-induced senescent fibroblast model, more SA--gal-positive cells were observed in keloid fibroblasts compared with that in normal skin fibroblasts (Fig

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These results suggest that the increased expression of GSTO2 could be the result of reduced BDNF transport in striatal tissue by mHTT followed by increased TH in the SNcVTA and subsequent striatal hyperdopaminergia (Fig

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