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sFRP4 signalling of apoptosis and angiostasis uses nitric oxide-cGMP-permeability axis of endothelium

FDA's staff reviewers said before the meeting they couldn't find strong evidence to support any of those uses

Not because it works

Oral quercetin has limited absorption, while IV quercetin achieves full bioavailability

FDA staff and opposing groups argue that adding these compounds to the legal compounding list without adequate human safety data would legitimize unvetted foreign supply chains and create a false assurance of safety through the appearance of regulatory sanction