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The ripple effects of GLP-1 therapies are poised to touch every corner of medicine

And, with the dismal results of the clinical trials, do we have any reason to believe that a GLP-1-targeted strategy might do better

SBP reduction was mostly mediated by weight loss (7794%) in SURPASS-1, -2 and -3, while mechanisms independent from weight loss accounted for most of the tirzepatide benefit on SBP in SURPASS-4 and -5 (57 and 73%, respectively) [77]

Patients should not stop or change these medications without consulting their healthcare provider

There is no universally correct choice among these options

The Medicines and Healthcare products Regulatory Agency (MHRA) continues to monitor the safety profile of these medications