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In comparison to ferroptosis-resistant cells, cells sensitive to ferroptosis accompanied by RAS mutation exhibit elevated TFR1 expression and reduced ferritin expression, indicating that higher iron import and lower iron storage may lead to ferroptosis (Yang and Stockwell, 2008)

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Only under these conditions will it be possible to determine whether selective stabilization of the mitochondrial hub can move from mechanistic plausibility to clinically meaningful intervention (95)

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