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While substantial, it is far lower than the risk attributed to diabetes (HR 10.7) or metabolic syndrome (HR 6.1), and slightly lower than elevated blood pressure (HR 4.6)

These combine nutrition education, exercise planning and behavioral coaching

The inhibitory effect is presumably mediated indirectly through somatostatin secretion, but a direct effect cannot be completely excluded

In ALS, GLP-1 analogues have extended survival in preclinical studies

In type 2 diabetes mellitus, portal vein insulin levels are elevated to compensate for the insulin-resistant state of the body

2 Majority of patients were treated with standard of care 1,2,n,o Summary of medication at baseline (N=3533) 1,2 Select CV and CKD baseline characteristics (N=3533) 1,2 n At baseline patients in FLOW were receiving standard-of-care background therapy, including a maximum tolerated label dose of a RAAS-blocking agent including an ACE inhibitor or an ARB, unless such treatment was contraindicated or not tolerated