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Weight loss rate significantly impacts outcomes

doi: 10.1056/NEJMoa2204041 5 AykutAOzenSGoksenDAtaAOnayHAtikTet al

A meta-analysis indicated that deep-brain stimulation improved on-medication motor scores on the Unified Parkinson Disease Rating Scale by 4.56 points (95% CI, 3.116.00) compared with the best drug therapy and off-medication scores by 15.50 points (95% CI, 12.6018.39)

Metformin has been shown to have some anti-inflammatory effects in clinical studies in patients with T2DM, in experimental studies in rodent models of obesity and T2DM, and in vitro experiments with several immune cells (Foretz et al., 2019

Future perspectives Clinically meaningful outcomes in patients with NAFLD/NASH are shown in Table 2