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The Michigan Neuropathy Screening Instrument Questionnaire and Examination (MNSIQ and MNSIE) was used to measure the vibration perception threshold (BIO) and Cardiovascular Autonomic Reflex Tests (CARTs)

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Our meta-analysis showed that the overall effect size of N -acetylcysteine was moderate (SMD = 0.77) and comparable with the antidepressant effect sizes of aripiprazole (SMD = 1.35), haloperidol (SMD = 0.82), and risperidone (SMD = 0.59), as indicated by a previous meta-analysis [56]

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