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Criteria used for validation of VO 2 peak were completion of at least the first 8 min of the test protocol and a respiratory exchange ratio (carbon dioxide production/oxygen consumption) 1.1 [32]

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The quality of FASTQ files was checked using fastQC, and then the reads were aligned to GRCh38 bt TopHat and Bowtie (57)

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Autophagy and the proteasome Large intracellular particles, including damaged mitochondria and protein aggregates, are degraded by a process known as autophagy