We demonstrate that two peptide biased agonists (GEP44 and GEP12) of the GLP-1, neuropeptide Y1, and neuropeptide Y2 receptors (GLP-1R, Y1-R, and Y2-R, respectively) elicit Y1-R antagonist-controlled, GLP-1R-dependent stimulation of insulin secretion in both rat and human pancreatic islets, thus revealing the counteracting effects of Y1-R and GLP-1R agonism
Development of orthogonal protecting group principles and solid phase synthesis have revolutionised the field
1/19 [5.3%] among those treated with either anti-PD-1 antibody, log-rank test, p = 0.001
Works on both GLP-1 and GIP receptors for enhanced appetite suppression and metabolic benefits compared to single-action medications
The synergy of L-carnitine and green tea
#bariatricsurgery #weightloss #glp1 #medication ##sleevegastrectomy #gastricbypass #medicine #surgery #healthcare original sound Sachin Kukreja MD Bariatrics In real-world use, bariatric surgery produces far greater and more durable weight loss than Ozempic and similar GLP-1 drugs