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Nature 500 , 541546 (2013)

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Although TET members such as TET2 functions as tumor suppressor in certain cancers including AML and glioma 45 , we showed that knockdown of individual TET members consistently abrogates the YBX1AMPK axis in liver and lung cancer cells, suggesting potential functional synergy among TET members in regulating local DNA demethylation, although the underlying mechanisms warrant further investigation

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The wetting solution consists of sterile saline, local anaesthesia, and medication that constricts blood flow, reducing bleeding, bruising, and swelling