Glutamate-cysteine ligase protects cells from ferroptosis by decreasing glutamate levels, converting them to -glutamyl peptides, and boosting GSH production (36) ( Figure 1 )
Consequently, GLP-1 analogs are used for treatment of T2D and the GLP-1 analogs liraglutide and, more recently, semaglutide have been approved by the Food and Drug Administration to support weight loss in obesity (Trapp & Brierley, 2022)
The Collagen Connection Glutathione supports collagen synthesis in multiple ways
Neither medication is universally safer for every patient
and one 1-year, open-label trial that included 12 pediatric patients with POMC or LEPR deficiency or BBS aged 2 to less than 6 years (Trial 5) [see Clinical Studies (14.2, 14.3, 14.4)]
Current research is focused on designing drug candidates that would simultaneously address different mechanisms of high glucose in an individual and contribute to satiation, body weight control and patient convenience
