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Significance for Untargeted Metabolomics MoA Research This study illustrates the core value of metabolomics-based MoA characterisation: the activity difference between BSFL oil and its purified major fatty acid (C12:0) was only mechanistically interpretable through the lipid mediator metabolic landscape

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Brain Brain-derived GLP-1 is primarily produced in specific populations of neurons expressing the GLP-1 precursor, preproglucagon (PPG) in the nucleus tractus solitarus (NTS) of the hindbrain and project to multiple brain regions that express the GLP-1R

Oxidative stress contributes to these conditions by damaging endothelial cells and impairing their function [187]

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