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(Left) In liver cells, GLP-1 can mediate cholesterol efflux by acting directly on LXR, or by inducing an increase in ATP-binding cassette transporter A1 (ABCA1) mRNA through Ca2+/calmodulin (CaM)-dependent protein kinase kinase/CAM-dependent protein kinase IV/Prolactin regulatory element binding (CaMKK/CaMKIV/PREB), increasing apolipoprotein AI (apo AI) mRNA and promoter expression, and increasing apo AI secretion, thereby mediating intracellular cholesterol efflux

As we age, mitochondrial function typically declines, leading to reduced energy production and cellular efficiency

One cannot also fail to mention that the number of patients diagnosed with FCS/MCS (partly because of lack of knowledge on this diseases and complex genetic testing) is extremely small (up to 5000/2 million worldwide [139])

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When in doubt, consulting a healthcare professional can help ensure safe and effective use

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