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Animal studies show restored pineal signaling, and circadian rhythms of melatonin and cortisol improve in aging subjects, supporting its geroprotective profile in preclinical studies

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Moreover, like other medications in its class, there is a warning regarding the risk of thyroid C-cell tumors, based on animal studies, although its relevance to humans remains under investigation

(1995) Pharmacokinetics of losartan, an angiotensin II receptor antagonist, and its active metabolite EXP3 174 in humans

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