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Barrier breakdown allows more allergens in, which triggers more Th2 activation, which further weakens the barrier

Autoimmune diseases encompass a diverse group of conditions characterized by inappropriate immune system activation against self-antigens

We show that GLP-1(2836) entered mouse caSMCs and ECs by macropinocytosis and activated sAC, as evidenced by the increased production of cAMP in caSMCs from WT but not sAC / mice