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Results were also generally consistent whether evaluated according to the treatment policy estimand (regardless of trial product discontinuation or rescue medication use) or the trial product estimand (patient continuing on trial product and without rescue medication)

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After 1 h incubation at RT, the plate was read by an Envision plate reader (PerkinElmer) to measure TR-FRET signals (excitation: 320 nm, emission: 615 nm and 665 nm)

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