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PD-0200347, an 2 ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKC dependent effect

The conclusions from these essentially negative MR findings have, however, been questioned in a well-argued critique 31 , pointing out the limitations of genetic markers that explain only a small component (i.e., 7.7% at most 5 ) of serum UA variance and querying whether the core assumptions of MR, including the absence of confounds as well as a strong association with UA, are met

Full text: Chang, J., Leong, R

Supplementary Figure 10 Metabolic pathway enrichment analysis plot shows significantly altered pathways in A vs LC

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Unlike peptides that stimulate the release of growth hormone, IGF-1 LR3 acts further downstream within the growth hormone pathway