All individuals were anesthetized with medetomidine (Domitor, Nippon Zenyaku Kogyo Co., Ltd, Fukushima, Japan) [0.05 mg/kg intramuscularly (IM)] and ketamine hydrochloride (Ketalar, Daiichi Sankyo Co., LTD, Tokyo, Japan) (10 mg/kg IM), and then veterinarians pressed their bladders gently to collect their urine samples
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As for the mechanisms of hypotensive effect beyond BW, augmentation of natriuresis by inhibiting sodium hydrogen exchanger at proximal tubule, ameliorating angiotensin II activity, and enhancing vasodilation can be postulated
Robinson DS (1998) T cell co-stimulation: a potential therapeutic target in asthma
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First, this study was based on the largest number of participants with the longest period of treatment (up to 24 weeks)