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3 Time-averaging plots of the white light curve fit residuals for the three observations (a-c) and the phase-folded data (d)

The primary concern for the FDA was the lack of large-scale, randomized controlled trials, which are the gold standard for new drug approval

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The nine tissue systems now documented in the preclinical literature were not predicted by computational models or receptor-binding assays at the outset they were identified sequentially as researchers in different laboratories independently tested the compound against different experimental injury models and consistently found meaningful effects

Longer uninterrupted dosing is not recommended because receptor sensitivity can diminish without cycling