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These effects were achieved under reduced activation of noncanonical signaling pathways including receptor internalization and -arrestin recruitment, an initially surprising observation as these have previously been linked to increased GLP-1R responses when measured acutely 10,14,36

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Immunofluorescence Primary cultured tubular cells were seeded at the density of 5 10 4 cells/well on an 8-well open -slide chambered coverslip