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To clarify how the TSS pathway is activated, we first evaluated the effects of hypoxia in the presence of supraphysiological concentrations of cystine

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[,] Lycopene also plays a role in apoptosis, cytoprotection, androgen receptor (AR) signaling, and the protein kinase B (Akt)/mechanistic target of rapamycin (mTOR) cascade, all contributing to its potential as a chemopreventive agent (Figure 3)