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Further escalation to 1 mg or 2 mg occurs at intervals of at least 4 weeks based on glycaemic control and tolerability

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Those whose insurance covers the drug could pay less, but not many insurance plans cover the drug for weight-loss purposes

Nat Rev Endocrinol 22 , 242254 (2026)

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Clinical trials have found that tirzepatide can produce greater average weight loss than semaglutide, in some cases by several additional percentage points