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This analysis concludes that while GLP-1 agonists demonstrate significant promise, their ultimate impact depends on addressing cost, accessibility, and long-term sustainability concerns

doi:10.1093/ofid/ofae093

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Notably, GLP-1-producing neurons within the nucleus tractus solitarius (NTS) project axons to the VTA and other limbic structures, further embedding GLP-1 signaling within neural networks that regulate reward and motivation (Llewellyn-Smith et al., 2011