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Alternative protocols include: Daily low-dose: 750 mcg daily for 3 months, then cycling one month off

Endogenous GLP-1 has a short half-life (23 minutes) and is rapidly metabolised after its secretion via the enzyme dipeptidyl peptidase (DPP-4), while GLP-1RAs have a prolonged half-life of approximately 7 days [2, 3], resulting in some long-lasting effects

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Controlled Release 142 , 4046 (2010)

Visible changes were observed in the hippocampus, as illustrated in Figure 3