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Exendin-4 exerts osteogenic actions in insulin-resistant and type 2 diabetic states

it has no MHRA or EMA marketing authorisation as of July 2025

These drugs mimic the action of natural GLP-1, enhancing its beneficial effects on weight and blood sugar control

Supply shortages of Wegovy and others may impact successful treatment

Meanwhile, Eli Lilly is juggling lawsuits filed by Trulicity patients who allege they suffered severe, unexpected complications after taking Trulicity

Likewise, once a week administration of efpeglenatide, a long acting GLP-1RA, significantly reduced the body weight in obese patients (172)