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The olfactory bulb is the basic brain region responsible for olfactory information

doi: 10.1001/JAMAINTERNMED.2022.0338 114 McCleanPLGaultVAHarriottPHlscherC

Trial results vary by drug, dose, baseline weight, adherence, side-effect tolerance, and whether patients can stay on treatment

These are signs that the glucagon component is driving energy expenditure at a level that meaningfully contributes to the overall weight loss beyond what GLP-1 and GIP provide alone

Patients considering GLP-1 medications should consult their healthcare provider to discuss whether pharmaceutical intervention is appropriate for their specific clinical situation, including consideration of cardiovascular risk factors, degree of hyperglycemia, and previous response to lifestyle interventions

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