In the Phase 3 TRIUMPH-4 trial, 33% of participants on the 12 mg dose reported diarrhea compared to 13.4% on placebo (Wang et al., Syst Rev Meta-Analysis, 2025)
These references are included for educational purposes only and do not constitute claims of safety, efficacy, or approval for human or animal use
Placebo (FOURIER trial, N=27,564) Monitoring recommended / fasting lipid panel every 4 to 12 weeks after initiation Prescriber disclosure / always required for any new supplement How Repatha (Evolocumab) Works and Why Metabolism Matters Evolocumab is a fully human IgG2 monoclonal antibody that binds proprotein convertase subtilisin/kexin type 9 (PCSK9), blocking PCSK9 from degrading LDL receptors on hepatocytes
While it is often discussed in the context of skin tone, its primary function is protecting your cells
Those with medium to dark complexions have more active melanocytes, so they tan faster and retain pigment longer
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