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This is the perfect place to ask, "Is this side effect normal?" or "Should I adjust my dose?" Dose Adjustments: If side effects are bothersome, your provider might suggest delaying a dose increase or adjusting your titration schedule to give your body more time to adapt

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A principled approach is to introduce compounds one at a time, establish a baseline, and observe carefully before adding another

Meanwhile, mechanisms provided by microbial metabolites and the local immune system restore normal mechanosensitivity