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Dual melanocortin-4 receptor and glp-1 receptor agonism amplifies metabolic benefits in diet-induced obese mice

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Docking scores were obtained for each molecule that could be successfully docked into the active site of GPx1, and molecules were subsequently ranked based on their Chemgauss4 docking score [33].Only molecules that ranked within the top 150 docking scores (top 10%) for each model (1GP1 or 2F8A) were considered for subsequent pharmacoepidemiological analyses as these drugs were more likely to potently bind to the target and exert their effects [40,41,42,43]