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This phenomenon, sometimes called tolerance or tachyphylaxis, is not well-studied specifically for semaglutide, but it is reported frequently in practice

"Primary Mechanisms of Thymosin 4 Repair Activity in Dry Eye Disorders and Other Tissue Injuries." Investigative Ophthalmology & Visual Science

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GHK-Cu binds with copper ions to activate cellular pathways involved in collagen and elastin synthesis, wound healing, and tissue remodeling

doi: 10.1021/acsptsci.4c00358 40 WaibelMChristiansenAJHibbsMLShorttJJonesSASimpsonIet al