We estimated that with this sample size, the study would have 80% power to detect an absolute difference in the rate of improvement in ALT of 30 percentage points, with a two-sided type 1 error of 0.05
A-GSH targeting resulted in a time-dependent increase in the cellular internalization of 3-PLGs conjugated with active agents (Figs
LC separation, which followed the previously reported procedure 28 , was performed using a normal-phase (hydrophilic interaction chromatography, HILIC) column (ZIC-pHILIC
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this results in reduced transcription of mitochondrial ribosomal proteins and mitochondrial transcription factors, and subsequently halting protein translation 101,102
also designated TDG) yielding -amino--ketobutyrate (2-amino-3-ketobutyrate)