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(26) employed 630 nm LED irradiation on the knee joints of KOA model rats, observing that this treatment significantly increased the activity of endogenous antioxidant enzymes (SOD and catalase) in OA joints, reduced levels of lipid peroxidation damage markers such as thiobarbituric acid reactive substances (TBARS), and effectively mitigated oxidative stress-induced damage to chondrocytes

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Emergency department utilization is particularly elevated, with 67% of women visiting emergency departments for pain-related complaints before receiving their diagnosis (Fuldeore & Soliman, 2017)

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