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Of the 40 and 45 participants who were randomized to exercise alone or combined treatment and completed the study, 26 (65%) and 29 (64%) were per-protocol

B Vitamins (like B12 and B6): These are the workhorses of energy metabolism

These medicines can improve blood sugar control, support weight reduction, and lower cardiovascular or kidney risk in the right patient

Additionally, some participants experienced diarrhoea severe enough to discontinue treatment, highlighting the clinical relevance of these side effects on electrolyte balance

This hybrid diuretic effect, which couples natriuresis with osmotic diuresis, potentially leads to systemic RAAS activation